Biochemistry (BCH)

BCH 225 Introduction to Organic and Biochemistry 4 Credits

An introductory course describing the basic principles of organic chemistry and biochemistry as they relate to human metabolism and disease. The nature of the chemical structure and reactivity of organic functional groups such as alcohols, aldehydes, ketones, carboxylic acids and amines will be presented with biological processes in mind. The biochemistry of the macromolecules DNA, RNA, proteins, carbohydrates and lipids will be discussed leading in to a discussion of some of the more important metabolic pathways. This course is intended for science majors who do not take the full two semester sequence of organic chemistry and two semesters of biochemistry and desire a background in biochemistry. Non-science major students who have had one semester of general chemistry and one semester of biology may also enroll in the course. Three hours of lecture and one three-hour lab per week. Prerequisite(s): CHE 120, CHE 121; BIO 115 or BIO 117.

Corequisite(s): BCH 225L.

BCH 225L Introduction to Organic & Biochemistry Lab 0 Credits

This lab is a co-requisite and must be taken with the corresponding course.

Corequisite(s): BCH 225.

BCH 325 Biochemistry I 3 Credits

Outlines the chemistry and biological function of carbohydrates, proteins, lipids, nucleic acids, vitamins, and enzymes, and introduces enzyme kinetics and biological energetics. Degradative metabolic pathways of carbohydrates and lipids, and their controlled interrelationships are discussed in detail.

Prerequisite(s): CHE 214.

BCH 326 Biochem and Enzymology I Lab 1 Credits

The laboratory work illustrates techniques and methods essential to the biochemist. Methods for quantification of proteins, purification of enzymes and determination of their kinetic parameters, polarimetry, and structure proof of carbohydrates. The lab must be taken concurrently with BCH 325 by biochemistry and biology majors, but is optional for others.

Prerequisite(s): CHE 123, CHE 214.

BCH 330 Biochemistry II 3 Credits

Continuation of Biochemistry I. Includes molecular analysis of biological membrane structure and function and a molecular level analysis of information flow from DNA through RNA to proteins. Other topics include mechanisms of hormone action and an expansion on metabolic concepts.

Prerequisite(s): BCH 325.

BCH 331 Biochemistry II Lab 1 Credits

Methods of protein analysis, building on techniques and principles learned in BCH 326. Students will use bioinformatics and molecular biological techniques, including PCR, to harness and change protein sequence. They will implement modern protein purification techniques, develop enzyme essays, and perform equilibrium binding assays to investigate the relationships among protein sequence, structure, and function.

Prerequisite(s): BCH 326, BIO 117.

BCH 425 Medicinal Chemistry 3 Credits

A comprehensive description of the important principles of medicinal chemistry including principles of rationale drug design with synthetic strategies, mechanisms of drug actions, structure-activity relationships, the absorption, distribution, metabolism and elimination of drugs. Specific classes of drugs to be discussed include: anticancer agents, analgesics, anti-inflammatory drugs, steroids, drugs acting on the nervous system and antibiotics.

Prerequisite(s): BCH 325 or permission of instructor.

BCH 490 Independent Research and Study 1-4 Credits

Immerses the student in laboratory research. The student learns to organize material, use the literature, make precise measurement, and obtain reproducible data. If possible, the student will publish the results or present them at a scientific meeting.

BCH 491 Internship in Biochemistry 1-4 Credits

A supervised research experience in an approved organization where qualified students gain real-world knowledge and utilize their academic training in a professional environment. Placement may be in private, public, non-profit or governmental organizations under the guidance of a mentor. The mentor and student will have regular consultation with the departmental internship coordinator to assess the student’s progress. Normally, 50 hours of internship per credit is required. The grade for the course will be determined by the students’ overall performance in their research work, a research paper documenting their work with their internship mentor and an oral or poster presentation at the end of the semester.

Prerequisite(s): 2.5 GPA and permission of the instructor.